Fig. 2
From: Putting human Tid-1 in context: an insight into its role in the cell and in different disease states
Role of hTid-1 in various cellular processes. A hTid-1 acts as a co-chaperone causing conformational changes in Hsp70/Hsc70 which helps it to interact with Jak2 kinases, thereby inhibiting it. B hTid-1 along with Hsp70/Hsc70 interacts with IκB and helps in cell growth. C hTid-1L causes the attachment of poly-ubiquitin chains to ErBb2 which leads to its subsequent degradation via the proteasomal pathway. D hTid-1 causes the attachment of poly-ubiquitin chains to EGFR which leads to its subsequent degradation via the proteasomal pathway. E hTid-1 plays an important role in autophagic degradation by interaction with the Beclin1-PI3 kinase class III protein complex