Fig. 1
From: Putting human Tid-1 in context: an insight into its role in the cell and in different disease states
hTid-1 Splice Variants: hTid-1L A and hTid-1S B comprise distinct functional domains i.e., the amino-terminal (NT) signal sequence (having mitochondrial targeting sequence that targets the protein into the mitochondria), a DnaJ domain, a Cysteine-rich domain resembling a zinc finger repeat sequence (CXXCXGXG), and a non-homologous carboxy-terminal domain (CT). hTid-1L has a set of 33 unique amino acids at its C-terminal end, while hTid-1S has a set of 6 unique amino acids at its C-terminal end. Both hTid-1L and hTid-1S have a predicted mitochondrial processing sequence (LRP-GV) in the NT domain, which is cleaved at amino acid 66 upon entry into the mitochondria. (C). hTid-1 isoform 3 has 300 amino acids and differs from hTid-1L and hTid-1S by a unique sequence of amino acids from 3 to 186