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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells

Fig. 7

Dominant roles of PI3Kβ in EGF-induced CDR formation. A Representative confocal images of actin in Hep3B with or without p110α inhibitor (A66) or/and p110β inhibitor (TGX221) treatment after EGF stimulation. Arrows indicate CDRs. (B Quantification of the frequency of CDRs after stimulation by EGF with/without p110 inhibitors from three independent experiments. TGX221 completely blocked CDR. *P < 0.05, ****P < 0.0001, by one-way ANOVA. C A66 completely blocked EGF-stimulated (5 min) pAKT. TGX211 attenuated pAKT around 50%. D Quantification of pAKT/AKT ratios after EGF stimulation (5 min) with/without p110 inhibitors from 3 independent experiments. Results are indicated as arbitrary units (AU). ***P < 0.001, ****P < 0.0001, by one-way ANOVA

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Cell Communication and Signaling

ISSN: 1478-811X