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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

Fig. 3

AMPK activation induces caspase-independent cell death. A Percent dead cells of A549 expressing LKB1 transgene (A549-LKB1) and A549 LKB1 null transfection control cells (A549-Puro) treated with JL5 and Ym155 alone and in combination for 48 h. Data represents mean of 6 studies. B Western blot analysis of A549-LKB1 A549-Puro cells treated for 24 h. C Percent death cells of H1299 cells treated with AMPK allosteric activator for 48 h. Data represents the mean of 4 studies. D Immunoblots of cells treated for 24 h. E Immuno blot of cells treated for 24 h. F, G Mean percentage of dead H1299 cells after treatment with JL5 and Ym155 in combination for 24 h with and without Z-VAD-FMK or necrostatin, n =  = 4

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Cell Communication and Signaling

ISSN: 1478-811X