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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

Fig. 2

Synergistic growth suppression and enhanced AMPK activation with BMP inhibition when combined with phenformin in LKB1 competent cells. A, C Mean percent live cells of 4 experiments of H1299 and A549 cells treated with BMP inhibitors JL5, JL189, or phenformin alone and in combination for 48 h. Yellow table represents the combination index (CI) of cells treated with phenformin plus BMP inhibitor at each concentration. Concentration of drugs used increase from left to right. B, D Representative immunoblot of A549 and H1299 cells treated with BMP inhibitors JL5, JL189, or phenformin alone and in combination for 24 h. E, F Mean live and dead cells of A549-Puro and A549-LKB1 cells treated with phenformin for 48 h, n = 4. G, H Mean live and dead cells of A549-Puro and A549-LKB1 cells treated with phenformin and JL5 for 48 h, n = 4

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Cell Communication and Signaling

ISSN: 1478-811X