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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

Fig. 1

Mitochondrial inhibitor Ym155 and BMP inhibitors enhance AMPK activation and induce more cell death in LKB1 competent cells. A Mean percent cell death of 4 experiments of H1299 and A549 cells treated with Ym155 for 24 h. Mean percent death and percent live cells of 4 experiments of A549-LKB1 and A549 wild-type cells treated with Ym155 (B, C). D, F Mean percent live cells of 4 experiments of H1299 and A549 cells treated with BMP inhibitors JL5, JL189 or Ym155 alone and in combination for 48 h. Yellow table represents the combination index (CI) of cells treated with Ym155 plus BMP inhibitor at each concentration. Concentration of drugs used increase from left to right. E, G Representative immunoblots of A549 and H1299 cells treated with BMP inhibitors JL5, JL189, or Ym155 alone and in combination for 24 h. H Cell counts of primary lung cancer samples treated with JL5 and Ym155 alone and in combination for 48 h. I Primary lung cancer samples were treated for 36 h and nuclei stained with DAPI. Scale bar is equal to 10 μm. (J) Western blot analysis of primary tumors

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Cell Communication and Signaling

ISSN: 1478-811X