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Table 3 Histology assessment of kidneys injury in control and PKM2 KO mice. We examined the tubules of the cortical and corticomedullary areas using PAS-stained renal sections obtained from PBS or LPS-treated wild type (Ctrl) and podocyte PKM2 knockout (KO) mice and scored the degree of injury as detailed in the methods section

From: Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin

 

Cortical area

Corticomedullary junction

Ctrl-PBS

1.36 ± 0.78

0.85 ± 0.41

KO-PBS

0.51 ± 0.23

0.22 ± 0.10

Ctrl-LPS

16.29 ± 6.59*

14.54 ± 5.78*

KO-LPS

2.77 ± 1.16*#

2.61 ± 1.19#

  1. *p < 0.05 indicates a significant difference between PBS- and LPS-injected mice. #p < 0.05 indicates a significant difference between Ctrl and KO mice
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Cell Communication and Signaling

ISSN: 1478-811X