Fig. 5

Penfluridol in combination with CC effectively suppresses the tumor xenografts in vivo. A The working model shows the process of our animal studies. Mice were transplanted with tumor tissues for 10 days and randomly divided into four groups (control, CC (10 mg/kg), PF (10 mg/kg), CC + PF; n = 5/group). Then, the tumor-bearing mice were treated with intragastric administration and intratumor injection with a dissolvent, intratumor injection with CC, intragastric administration with PF, and CC + PF co-treatment. All mice were sacrificed on day 15, and the tumors were collected for subsequent experiments. B The body weight change of mice after indicated treatment. C Tumor weight of the mice. D Tumor growth curves of tumor tissues after indicated treatment. E Photograph of the transplanted tumors after indicated treatment. F Western blotting assay result of the tumors with indicated treatment. G The H&E results and IHC staining assay for Ki-67, Cleaved-caspase3, p-AMPK T172 of the tumors. **P < 0.01, ****P < 0.0001