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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth

Fig. 3

Activation of AMPK/PFKFB3 signaling pathway mediated the glycolysis after penfluridol treatment. A The Western blot of SGC-996, EH-GB1, and GBC-SD cells treated with PF as indicated for 24 h. B, C The glucose consumption and lactic acid production ability of SGC-996, EH-GB1, and GBC-SD cells treated with control and PF (5 μM) in the presence or absence of AMPK si-RNA. D, E The glucose consumption and lactic acid production ability of SGC-996, EH-GB1, and GBC-SD cells treated with control and PF (5 μM) in the presence or absence of A-769662 (100 μM). F The Western blot of SGC-996, EH-GB1, and GBC-SD cells treated with control and PF (5 μM) in the presence or absence of AMPK si-RNA. G The Western blot of SGC-996, EH-GB1, and GBC-SD cells treated with control and PF (5 μM) in the presence or absence of A-769662 (100 μM). **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X