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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth

Fig. 2

Inhibition of glycolysis enhanced the anticancer effects of penfluridol. A, B The glucose consumption and lactic ability of SGC-996, EH-GB1, and GBC-SD cells treated with PF as indicated for 24 h. C, D The glucose consumption and lactic ability of SGC-996, EH-GB1, and GBC-SD cells treated with control, 2-DG (2 mM), PF (5 μM), or 2-DG + PF. E The colony formation of SGC-996, EH-GB1, and GBC-SD cells treated with controls, 2-DG (1 mM), PF (1 μM), or 2-DG + PF for 14 days. F Annexin V/PI apoptosis assay of SGC-996, EH-GB1, and GBC-SD cells were with control, 2-DG (2 mM), PF (5 μM), or 2-DG + PF for 24 h before Annexin V/PI assay. G Western blot of SGC-996, EH-GB1, and GBC-SD were treated with control, 2-DG (2 mM), PF (5 μM), or 2-DG + PF. **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X