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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Fig. 3

HAND2 reconstitution could repress cell proliferation, invasion and migration. a In DLD1 and RKO cells, HAND2 overexpressing plasmid (pcHAND2) or control vector (pcDNA3.1) were transfected with cells. Protein level of HAND2 were greatly increase after reconstitution, which revealed the successful construction of HAND2 overexpressing cells. b The invasion and migration capacities in DLD1 cells with HAND2 reconstitution (pcHAND2) were decreased than control cells (pcDNA3.1) by 24-well transwell assays (n = 3). c Cells with HAND2 reconstitution (pcHAND2) could inhibit cell proliferation than control cells (pcDNA3.1) by RTCA assay in both DLD1 and RKO cells (n = 3)

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Cell Communication and Signaling

ISSN: 1478-811X