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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway

Fig. 3

TRIM15 associates with Keap1. A Network graph representation of interaction from the BioGRID for TRIM15. Users can select the ‘Network’ tab from the ‘Switch View’ menu to view interactions data when available. B Immunoblot detection of the indicated proteins in a Co-IP assay performed in HEK293 cells. C Immunofluorescence colocalization of TRIM15 with Keap1 in H1299 and H1975 was assessed by rabbit anti-TRIM15 detected with anti-rabbit IgG-Alexa Fluor 488 (green fluorescence), and detection of Keap1 with mouse anti-Keap1 detected with anti-mouse IgG Alexa 594 (red fluorescence). The colocalization of TRIM15 and Keap1 is illustrated by overlay of the images, illustrated by yellow fluorescence. D Immunoprecipitation assay revealing the interaction between TRIM15 with Keap1 in H1299 and H1975 cells. E Co-localization of TRIM15 (green) and Keap1 (red) in 2 NSCLC tissues from two patients by immunofluorescent confocal microscopy

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Cell Communication and Signaling

ISSN: 1478-811X