Fig. 7

CAFs’ secretome analysis. To identify proteins secreted by CAFsCM’, conditioned media were used for cytokine (A, C) and angiogenesis (B, D) arrays. Based on obtained signals (A, B) quantitative analysis (C, D) was performed. Densitometric data were normalized to reference spots and are presented in a form of heatmaps, where darker red indicates a higher increase in signal. Abbreviations: CCL2, C-C Motif Chemokine Ligand 2; GM-CSF, Granulocyte–macrophage colony-stimulating factor; ICAM1, Intercellular Adhesion Molecule 1; IL6, interleukin 6; CXCL1, C-X-C Motif Chemokine Ligand 1; DPPIV, Dipeptidyl‐peptidase VI; PTX3, Pentraxin 3; IGFBP-2, Insulin-Like Growth Factor Binding Protein 2; VEGFA, vascular endothelial growth factor A; PIGF, Placental growth factor A; MIF, macrophage migration inhibitory factor; PDGF A, Platelet-derived growth factor; TIMP-4, tissue inhibitor of metalloproteinases 4; TSP-1, Thrombospondin 1; uPA, urokinase-type plasminogen activator