From: Regulation of epithelial-mesenchymal transition by protein lysine acetylation
Target molecule | Molecular type | The expression levels of target molecules during EMT | The regulator of target molecule | Histone modifier | Acetylation sites | Target cells | References |
---|---|---|---|---|---|---|---|
E-cadherin | EMT-related epithelioid marker | Down | miR-N5 | CBP | H3K56 | Prostate cancer cells | [33] |
E-cadherin | EMT-related epithelioid marker | Down | SIRT1 | SIRT1 | H4K16 | Prostate cancer cells | [34] |
E-cadherin | EMT-related epithelioid marker | Down | Snail1 | HDAC1, HDAC2 | H3, H4 | Kidney cells | [35] |
E-cadherin | EMT-related epithelioid marker | Down | Snail2 | HADC1, HADC2, HADC3 | H3K4, H3K56 | Lung carcinoma cells | [36] |
E-cadherin | EMT-related epithelioid marker | Down | ZEB1 | HDAC1, HDAC2 | H3, H4 | Pancreatic cancer cells | [37] |
EpCAM | EMT-related epithelioid marker | Down | ZEB1 | unknown | H3K9, H3K27, H4 | Lung cancer cells | [38] |
E-cadherin | EMT-related epithelioid marker | Down | CPEΔN | HDAC1, HDAC3 | H3K9 | Lung cancer cells | [39] |
E-cadherin | EMT-related epithelioid marker | Down | TRIM28 | unknown | H3K9 | Lung cancer cells | [40] |
E-cadherin | EMT-related epithelioid marker | Down | HOTAIR | CBP | H3K27 | Gastric cancer cells | [41] |
αSMA | EMT-related mesenchymal marker | Up | TGF-β1 | unknown | H4 | Lens epithelial cells | [42] |
αSMA | EMT-related mesenchymal marker | Up | TGF-β2 | unknown | H3K27 | Kidney cells | [43] |
N-cadherin | EMT-related mesenchymal marker | Up | Ajuba, Twist1 | CBP | H3 | Colorectal cancer cells | [44] |
vimentin | EMT-related mesenchymal marker | Up | unknown | unknown | H3 | Prostate cancer cells | [45] |
Snail1 | EMT-TF | Up | DOT1L | P300 | H3 | Breast cancer cells | [46] |
Snail2 | EMT-TF | Up | SND1 | GCN5, P300, | H3K9, H3K14, H3K18 | Ovarian cancer cells | [48] |
Snail2 | EMT-TF | Up | KLF10 | HDAC1 | H3K9, H3K27 | Lung adenocarcinoma cells | [49] |
Snail2 | EMT-TF | Up | TGF-β | HDAC1, HDAC3 | H3K56, H3K4 | HCC cells | [50] |
Snail2 | EMT-TF | Up | LncRNA RP11-367G18.1 | unknown | H4K16 | In head and neck cancer cells | [51] |
Twist 1 | EMT-TF | Up | HAUSP, HIF-1a | unknown | H3K56 a | Multiple cancer cells | [52] |
Twist 1 | EMT-TF | Up | Wnt/β-catenin, PI3-K signalings | unknown | H3K27 | Gastric cancer cells | [53] |
Twist 1 | EMT-TF | Up | LncRNA RP11-367G18.1 | unknown | H4K16 | In head and neck cancer cells | [51] |
Twist2 | EMT-TF | Up | ACOT12 | GCN5 | H3 | HCC cells | [54] |
ZEB1 | EMT-TF | Up | MEF2D | P300 | H3, H4 | Colorectal cancer cells | [55] |
ZEB2 | EMT-TF | Up | unknown | unknown | H3 | Prostate cancer cells | [45] |
ZEB1 | EMT-TF | Up | DOT1L | P300 | H3 | Breast cancer cells | [46] |
ZEB2 | EMT-TF | Up | DOT1L | P300 | H3 | Breast cancer cells | [46] |
GHET1 | EMT-related LncRNA | Up | unknown | unknown | H3K27 | HCC cells | [56] |
ROR | EMT-related LncRNA | Up | CBP | CBP | H3K27 | Retinoblastoma cells | [57] |
TINCR | EMT-related LncRNA | Up | CBP | CBP | H3K27 | Breast cancer cells | [58] |
PLAC2 | EMT-related LncRNA | Up | CBP | CBP | H3K27 | Oral squamous cell carcinoma cells | [59] |
ANCR | EMT-related LncRNA | Up | HDAC3 | HDAC3 | H3, H4 | HCC cells | [32] |