Fig. 1
From: Regulation of epithelial-mesenchymal transition by protein lysine acetylation
The acetylation of EMT-related cellular factors and their associated KATs and KADCs to initiate EMT. The acetylation of EMT-related signal transduction molecules in TGF-β, PI3-K, and JAK/STAT pathways, to enhance the expression of EMT-TF gene expression, and then acetylation of EMT-TFs, including Snail1, Snail2, Twist1, ZEB1, and other transcription factors, including KLF15, YY1, and c-Jun, to regulate EMT markers expression. Additionally, the modulation of the acetylation of E-cadherin and vimentin can also regulate EMT. The KATs and KADCs, which have identified to contribute to the regulation of the acetylation of EMT-related cellular factors also were added in the Figure. EMT-TFs, EMT-inducing transcription factors, Ac: acetylation