Fig. 2
From: Regulatory role of short-chain fatty acids in inflammatory bowel disease
Short-chain fatty acids (SCFAs) inhibit the progression of inflammatory bowel disease (IBD) by regulating innate immune sensors Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflam-masomes and play a role in inhibiting the progression of IBD. SCFAs not only inhibit TLR sig-naling but also inhibit TLR4 expression by suppressing the histone acetylation pathway. SCFAs also prevent the progression of IBD by regulating the assembly and attenuation of NLRP3 in-flammasomes. The Figures in this review were created with BioRender.com