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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

Fig. 5

D347-2761 inhibited primary tumor growth in humanized myeloma xenograft mouse model. A NSG mice were separated with two groups: control group and D347-2761 group (n = 6). Tumor bearing status was shown by high digital camera. B Tumor volume of each group was measured every 3 days. C Tumors were stripped and tumor size of control group and D347-2761 group was shown respectively. D Statistical analysis of tumor weights of each group. E Western blot analysis of c-Myc expression in primary tumors of control and D347-2761 group. β-actin was used to be internal control. Error bars: mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. F IHC staining analysis of c-Myc, Ki67 and PCNA in each group. Scale bars: 200 μm

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Cell Communication and Signaling

ISSN: 1478-811X