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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells

Fig. 7

Mechanisms of NSCLC cell proliferation, migration and invasion inhibition by CPX. CPX shows anti-tumor activities in NSCLC through arresting cell cycle, suppressing cell migration and invasion via the inhibition of EMT. CPX induces ROS generation, impairs mitochondrial respiration, and increases glycolysis capacity. The anticancer activity of CPX also depends on ROS and/or ROS-induced ER stress through PERK-eIF2α-ATF4-CHOP signaling pathway to initiate apoptosis in NSCLC cells

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Cell Communication and Signaling

ISSN: 1478-811X