Fig. 7
From: An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer
The expression patterns of OVOL2 and GLUT1 are critical for NF-κB signaling-induced NSCLC cell survival. A Cell proliferation was assessed in P65-overexpressing NCI-H1299 cells after knockdown of membrane GLUT1 to the control level. B Cell proliferation was assessed in OVOL2-knockdown NCI-H1299 cells after knockdown of membrane GLUT1 to the control level. C Cell proliferation was assessed in P65-overexpressing NCI-H1299 cells after reexpression of OVOL2 to the control level. D, E, F Photographs and growth curves of NCI-H1299 xenografts in nude mice. A total of 4 × 106 cells described in A, B, and C were injected subcutaneously into mice. Tumor growth was monitored regularly for 7 weeks, and the tumor volume was calculated weekly. The data are expressed as the means ± SDs; n = 6 per group. *, p < 0.05; **, p < 0.01