Fig. 5
From: An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer
OVOL2 inhibits the recruitment of P300 but facilitates the binding of HDAC1 to P65. A Endogenous co-IP assay between P300 and P65 in SK-MES-1 cells with or without OVOL2 overexpression. B HAT activity assay using the P65 immunoprecipitate from SK-MES-1 cells with or without OVOL2 overexpression and from NCI-H661 cells with or without OVOL2 knockdown. The data are expressed as the means ± SDs of three independent experiments. **, p < 0.01. C Endogenous co-IP assay between P300 and HDAC1 in SK-MES-1 cells with or without OVOL2 overexpression. D HDAC1 activity assay using the P65 immunoprecipitate from SK-MES-1 cells with or without OVOL2 overexpression and from NCI-H661 cells with or without OVOL2 knockdown. The data are presented as the means ± SDs of three independent experiments. *, p < 0.05 and **, p < 0.01