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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin

Fig. 7

The Hippo pathway plays an essential role in the regulation of the LH cascade. Early events: Following binding of LH to its receptor, CREB is activated and YAP1 is recruited in proximity to the transcription start site of the Areg promoter. The latter contributes to the rapid upregulation of Areg in response to the LH stimulus. High extracellular levels of AREG contribute to the activation of the EGFR and downstream ERK1/2 pathway, and to the regulation of several LH-dependent genes. Delayed events: Granulosa cell stimulation by LH subsequently activates the Hippo pathway, resulting in YAP1 phosphorylation through a PKA-dependent mechanism. This Hippo activation is thought to be necessary for the transient expression pattern of Areg and for prolonged LH effects. Dashed arrows indicate a relation for which unidentified intermediate effectors may be involved. Created with BioRender.com

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Cell Communication and Signaling

ISSN: 1478-811X