Fig. 4

E2 alleviated myocardial infarction and reduced cTn I level by upregulating SERCA2a. a The electrocardiography of rats during the establishment of the MI/R model. b CTn I levels of each group (n = 3). c Representative photographs of Evans blue/TTC-stained heart sections in each group. d Area at risk of each group. e Percentage of infarction size of each group (n = 3). d *P < 0.05, **P < 0.01, ***P < 0.001 vs. sham; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. OVX; ^$P < 0.05, ^$$P < 0.01, ^$$$P < 0.001 vs. OVX + E2; ^%P < 0.05 vs. I/R; ^@P < 0.05, ^@@P < 0.01, ^@@@P < 0.001 vs. OVX + I/R; ^&P < 0.05, ^&&P < 0.01 vs. OVX + E2 + I/R; ^{^}P < 0.01, ^{^^}P < 0.01 vs. Ad-EGFP + I/R