Fig. 2

E2 reduced ER stress-related proteins by upregulating SERCA2a. a Protein levels of CHOP, CRT, caspase 12, and GRP78 in vivo (n = 3; *P < 0.05, **P < 0.01, ***P < 0.001 vs. sham; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. OVX; ^$P < 0.05, ^$$P < 0.01, ^$$$P < 0.001 vs. OVX + E2; ^%P < 0.05, ^%%P < 0.01, ^%%%P < 0.001 vs. I/R; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001 vs. OVX + I/R; ^@P < 0.05, ^@@P < 0.01 vs. OVX + E2 + I/R; ^{^}P < 0.05 vs. Ad-EGFP + I/R). b Protein levels of CHOP, CRT, caspase 12, and GRP78 in vitro (n = 3; *P < 0.05, **P < 0.01, ***P < 0.001 vs. con; ^#P < 0.05, ^##P < 0.01 vs. H/R; ^$P < 0.05, ^$$P < 0.01 vs. E2 + H/R; ^%P < 0.05, ^%%P < 0.01 vs. Ad-EGFP + H/R; ^&P < 0.05, ^&&P < 0.01 vs. Ad-SERCA2a + H/R; ^@P < 0.05, ^@@P < 0.01 vs. si-NC + H/R; ^{^^^}P < 0.001 vs. si-SERCA2a + H/R; ^aaaP < 0.001 vs. Ad-SERCA2a + E2 + H/R)