Fig. 1
From: MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells
Molecular mechanisms of microRNAs involved in regulation of TKIs responses in lung tumor cells. All of the microRNAs that targeted the RTKs were involved in increased TKIs sensitivity in lung tumor cells. MiR-214, miR-21, and miR-23a promoted TKIs resistance through PTEN targeting. SNHG14 and LINC0060 also increased TKIs resistance by miR-206-3p and miR-149-5p targeting and following ABCB1 and IL-6 up regulations in lung tumor cells. MiR-3127-5p and miR-146b-5p were also involved in increased TKIs sensitivity through ABL and IRAK1 targeting, respectively. (Created with BioRender.com)