Fig. 1

ucMSC-Evs alleviate anti-Thy 1.1-induced MsPGN in rats. A a flow chart for MsPGN induction in rats using anti-Thy-1.1; B, 24-h urine protein level in rats; C, D, serum creatinine (C) and Cys-C (D) levels in rats; E, pathological changes in mouse renal tissues observed by HE staining; F, the concentration of glycogen in the renal tissues in MsPGN rats determined by PAS staining; G, fibrosis in rat renal tissues determined by Masson's trichrome staining; H, I staining intensity of α-SMA (H) and PCNA (I) in renal tissues determined by IHC staining. N = 6 in each group. Data were expressed as the mean ± SD. Each spot indicates a single rat. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. ***p < 0.001 versus sham group; ##p < 0.01, ###p < 0.001 versus MsPGN + PBS; @ p < 0.05, @@ p < 0.01 versus MsPGN + 20 μg/mL ucMSC-Evs; n.s. represents no significance