Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway

Fig. 6

A schematic diagram showing the mechanism of action underlying the synergistic effect of the combination treatment. A schematic diagram showing the combination of WNT974 and ART increases ANAPC2, β-TrCP and GSK-3β expressions that lead to KRAS protein degradation via the ubiquitination ubiquitin–proteasome pathway. And then combination treatment inhibits CRC growth by suppressing PI3K/Akt/mTOR pathway

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X