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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway

Fig. 5

Combination of WNT974 and ART exhibits a potent anti-CRC effect in vivo. A The photographs of the CRC-bearing xenograft mouse model in different treatment groups. B Tumor volume, C % increase in tumor growth and D body weight of the mice. E Protein expressions of KRAS, β-TrCP, GSK-3β and ANAPC2 in the tumor tissues. F IHC analysis of the tumor tissues for KRAS, β-TrCP and GSK-3β (magnification × 200, Scale bars, 100 μm). Shown is mean ± SE, n = 5 mice in each group, *p < 0.05, **p < 0.01, *** p < 0.001 compared to control; a < 0.05, aa < 0.01, aaa < 0.001, compared to ART; b < 0.05, bb < 0.01, bbb < 0.001 compared to WNT974

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Cell Communication and Signaling

ISSN: 1478-811X