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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Role of store-operated Ca2+ entry in cardiovascular disease

Fig. 1

Illustration of involvement of abnormal SOCE in cardiovascular diseases and possible underlying mechanisms. Upper arrows show activation of pathway. GPV1: glycoprotein V1; ITAM: immunoreceptor tyrosine-based activation motif; 5HTR2A: 5-hydroxytryptamine receptor 2A; PLCβ: phospholipase C beta; NFAT: nuclear factor of activated T cell; ASK1: apoptosis signal-regulating kinase 1; CaMKII: calmodulin kinase II; ERK1/2: extracellular signal-regulated kinase 1/2; IL-1β: interleukin-1beta; TNF-α: tumor necrosis factor-alpha; VSMC: vascular smooth muscle cell; HIF-1α: hypoxia inducible factor 1α; EPC: endothelial progenitor cells; PASMC: pulmonary artery smooth muscle cell

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Cell Communication and Signaling

ISSN: 1478-811X