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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis

Fig. 9

ECFC-derived exosomes repair vascular injury by rescuing autophagic flux through the miR-21-5p/SIPA1L2 axis in a rat atherosclerosis model. A Expression levels of miR-21-5p and SIPA1L2 in rats with different treatments were determined by qRT–PCR. Biological replicates = 3–6, and technical replicates = 3. B Protein levels of SIPA1L2 and autophagy-related proteins (LC3I, LC3II and p62) in rats with different treatments were determined by qRT-PCR and western blot assay. Biological replicates = 3, and technical replicates = 1. C The schematic diagram illustrates that ECFC-exosomes repair vascular injury by rescuing autophagic flux through the miR-21-5p/SIPA1L2 axis in a rat atherosclerosis model. Exos-miR inh ECFC-exosomes transfected with miR-21-5p inhibitor, Exos-NC inh ECFC-exosomes transfected with NC inhibitor, N.S. not significant; significant differences between different treatment groups are indicated as *P < 0.05 and **P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X