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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis

Fig. 2

ECFC-derived exosomes promote the proliferation, migration, and tube formation of ox-LDL-treated HMECs. A Representative images of Dio-labelled ECFC-exosomes absorbed by HMECs. Red arrowheads indicated ECFCs-exosomes. Biological replicates = 3, and technical replicates = 1. B Cell viability of ox-LDL-treated HMECs with or without ECFC-exosome treatment was determined using CCK-8 assay. Biological replicates = 6, and technical replicates = 3. C, E Cell migration of ox-LDL-treated HMECs with or without ECFC-exosome treatment was determined by wound healing assay. Biological replicates = 3, and technical replicates = 1. D, F The tube formation ability of ox-LDL-treated HMECs with or without ECFC-exosome treatment was determined by tube formation assay. Scale bars = 100 μm. Exos ECFCs-exosomes. Biological replicates = 3–5, and technical replicates = 1. N.S. not significant; significant differences between different treatment groups are indicated as *P < 0.05 and **P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X