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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Glycogen synthase kinase GSK3α promotes tumorigenesis by activating HIF1/VEGFA signaling pathway in NSCLC tumor

Fig. 7

GSK3α regulated tumor angiogenesis in a HIF1α-dependent manner in vivo. a Construction of A549 cell lines stably expressing vector + shnc, GSK3α + shnc, GSK3α + shHIF1α#1, and GSK3α + shHIF1α#2. Successful transfections were confirmed via western blot analysis. b Tumor growth curve; *p < 0.05. c Tumor images. d Tumor weight; *p < 0.05. e IHC assay results showing the micro-vessel density of xenograft tumors. f Statistical analysis for the micro-vessel density of xenograft tumors; *p < 0.05. g Western blots showing protein expression in xenograft tumors. h The mechanism through which GSK3α regulates the HIF1/VEGFA signaling pathway

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Cell Communication and Signaling

ISSN: 1478-811X