Table 1 List of different types of granules, with their components and characteristics
Types | Components | Release | Characteristics |
|---|---|---|---|
Primary granules (azurophilic) | MPO NE Cathepsin G Proteinase 3 Azurocidin α-defensins Lysozyme Proteolytic proteins BPI | MPO NE ARG1 | 1. Earliest formed 2. Last degranulated 3. The size is largest |
Secondary granules (specific) | Lactoferrin NGAL Cathelicidin Lysozyme Alkaline phosphatase, NADPH oxidase Collagenase | NGAL S100A8/A9 | 1. Second formed 2. Discharged before primary granules 3. Smaller than azurophilic granules |
Tertiary granules (gelatinase) | Cathepsin, Gelatinase MMP-9 MMP-8 Microbicidal materials | MMP-9, Heparin enzyme ARG1 | 1. Third formed 2. Discharged followed by secretory granules 3. Smaller than secondary granules |
Secretory granules | CR1, Plasma protein albumin CD13 CD14, CD16 | 1. Last formed 2. Discharged first 3. The size is smallest |