Table 2 Crosstalk between MSCs and hematologic malignancies/cell lines via gap junction and its effects
Type of malignancy/cell | Kind of gap junction's component(s) involved | Target | Results | References |
|---|---|---|---|---|
HL-60 and PBL-985 cells | Cx43 | HL-60 and PBL-985 cells | Downward trend in differentiation potential | [56] |
U937, KG-1, KG-1a, HL-60, OCI-AML3, MV4-11, MoLM-13 Jurkat, and THP1 cells | Cx25, Cx26, Cx30, Cx31, Cx32, Cx36, Cx37, Cx40, Cx46, and Cx62 | MSCs | Proliferation | [56] |
Primary AML cells | Cx26, Cx32, Cx37, Cx43, and Cx45 | AML cells | Chemoresistance, ↓ apoptosis | [50] |
MM cells: RPMI 8226, U266, and XG-7 | Cx43 | MM cells | ↑Cell proliferation, chemoresistance | [57] |
AML | Cx43 | MSCs | Pathogenesis, chemoresistance | [53] |