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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells

Fig. 6

Role of UHMK1 in 5-FU exposure and release in HCT-8 cells. a Morphology changes of CBs in 1 μg/ml 5-FU and removal. Significant differences in all the 5-FU drug maintain groups of 1, 2 and 3 days compared to 0 d controls (p < 0.01); significant differences in all the release groups of 2, 4, 6 days compared with 0 d group (p < 0.01). b Western blots for coilin phosphorylation. c UHMK1 expression in the HCT-8 cells determined by RT-qPCR. p < 0.01 for all the 5-FU drug maintain groups of 1, 2 and 3 days compared to 0 d controls; p < 0.01 for all the release groups of 2, 4, 6 days compared with 0 d group. d Western blots for UHMK1 expression in the HCT-8 cells

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Cell Communication and Signaling

ISSN: 1478-811X