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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells

Fig. 5

Effects of UHMK1 overexpression in comparison to UHMK1 mutant lacks of kinase activity in HCT-8 cells. a Coilin phosphorylation in transfected HCT-8 cells. b Cell growth by CCK8 assays. c Dose-dependent survival from 5-FU treatments (0, 1, 5, 10, 20 and 40 μg/ml) for 48 h. d Cell growth in UHMK1 or mutant transfected HCT-8 cells with coilin knockdown. e Cell survival in coilin knockdown HCT-8 cells. Data were presented as the mean ± SD, n = 6. * p < 0.05 and ** p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X