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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway

Fig. 7

Inhibition of MET and EGFR blocks CPNE1-induced aberrant activation. A Inhibition of MET inhibits CPNE1-induced activation of the MET signaling pathway in A549 cells. B Inhibition of MET inhibits CPNE1-induced activation of the MET signaling pathway in HCC827 cells. C, E Inhibition of MET inhibits CPNE1-induced aberrant activation of cell proliferation. D, F Flow cytometric analysis showed MET inhibitors changed the percentage of cells in each cell cycle phase in CPNE1-overexpressing cell lines, as quantified on the right. G, H Dual blockade of MET and EGFR resulted in enhanced inhibition of downstream AKT and ERK pathways. I Dual blockade of MET and EGFR enhanced the inhibition of cell migration ability. *P < 0.05; **P < 0.01; ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X