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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway

Fig. 4

CPNE1 is positively related to RACK1 in NSCLC. A Differentially expressed proteins in PLVX- and CPNE1-overexpressing cells assessed by the mass spectrometry assay. B Immunofluorescence staining of CPNE1 and RACK1 in NSCLC cells. C The 25 most highly connected differentially expressed proteins in the protein–protein interaction analysis. D, E RACK1 protein levels were decreased in CPNE1-knockdown A549 and HCC827 cells. F Western blot analysis of CPNE1 and RACK1 protein levels in 14 paired NSCLC tissues and adjacent tissues. The right panel shows the relative quantification of CPNE1 and RACK1 protein levels. G, H CPNE1 and RACK1 interactions were detected in NSCLC cells by co-IP assays. *P < 0.05; **P < 0.01; ***P < 0.001

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