Fig. 6From: Scavenger receptors in host defense: from functional aspects to mode of actionSR-J/RAGE interacts with TLR4 receptor in response to synergistic interaction between HMGB1-LPS complex in activating the macrophages through phosphorylation of MAPK p38 and activation of NF-κB following release to proinflammatory molecules like IL16, IL1-β and TNF-αBack to article page