Fig. 3
From: Scavenger receptors in host defense: from functional aspects to mode of action
(a) LOX-1 on interaction with TLR2 on infection with PTX3 of Klebsiella Pneumonia shows OmpA internalization and stimulation of proinflammatory response. On binding to diverse microbial ligands it participates in antigen presentation on MHC class-I of dendritic cells in association with heat-shock protein HSP70. (b) Dectin-1 on binding to diverse antigens dimerize and activate CARD9, Bcl10, and MALT10, while on binding to TLR2/6 activates TRAF6, IRAK1, and IRAK4 leading to activation of proinflammatory cytokines and chemokines