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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Exosomes: the key of sophisticated cell–cell communication and targeted metastasis in pancreatic cancer

Fig. 3

Pex direct organ-specific metastasis via integrins. Pex can display different integrin proteins on their surface; ITGα6β4- and ITGα6β1-expressing exosomes preferentially interact with fibroblasts and epithelial cells in lung, and ITGαvβ5-expressing exosomes preferentially fuse with kupffer cells in liver. Once uptaken, Pex induce cellular changes in the target organ, thus promoting cancer cell colonization and organ-specific metastasis

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Cell Communication and Signaling

ISSN: 1478-811X