Table 3 FDA-approved exosomes in clinical trials for the treatment of pancreatic cancer

NCT03821909

Acquisition of Portal Venous CTCs and Exosomes From Patients With Pancreatic Cancer by EUS

Unknown status

Pancreatic Cancer

Procedure: Endoscopic ultrasound-guided protal venous blood sampling

NCT02393703

Interrogation of Exosome-mediated Intercellular Signaling in Patients With Pancreatic Cancer

Recruiting

Pancreatic Cancer|Benign Pancreatic Disease

NCT03608631

iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

Recruiting

KRAS NP_004976.2:p.G12D|Metastatic Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8

Drug: Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA

Phase 1

NCT03032913

Diagnostic Accuracy of Circulating Tumor Cells (CTCs) and Onco-exosome Quantification in the Diagnosis of Pancreatic Cancer—PANC-CTC

Completed

Pancreatic Ductal Adenocarcinoma (PDAC)

Pancreatic Ductal Adenocarcinoma (PDAC)

NCT03711890

Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

Recruiting

Pancreatic Carcinoma|Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

Procedure: Optical Coherence Tomography|Procedure: Therapeutic Conventional Surgery|Diagnostic Test: Laboratory Evaluation

Not Applicable

NCT03791073

New Biomarkers in Pancreatic Cancer Using EXPEL Concept

Active, not recruiting

Oncology

NCT03250078

A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals

Recruiting

Pancreatic Neoplasms

Diagnostic Test: MRI/MRCP

NCT04636788

Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer

Recruiting

Pancreas Adenocarcinoma

Procedure: Venous sampling

Not Applicable

NCT03410030

Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM)

Recruiting

Pancreatic Cancer|Pancreas Cancer|Pancreatic Adenocarcinoma Resectable|Pancreatic Ductal Adenocarcinoma|Pancreas Metastases

Drug: Ascorbic Acid|Drug: Paclitaxel protein-bound|Drug: Cisplatin|Drug: Gemcitabine

Phase 1|Phase 2

NCT03334708

A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma

Recruiting

Pancreatic Cancer|Pancreatic Diseases|Pancreatitis|Pancreatic Cyst

Diagnostic Test: Blood Draw|Diagnostic Test: Tumor Tissue Collection|Diagnostic Test: Cyst Fluid