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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Functional signaling test identifies HER2 negative breast cancer patients who may benefit from c-Met and pan-HER combination therapy

Fig. 3

HER2 and c-Met receptor are not overexpressed on test tumor cells. a Flow cytometry analysis of HER2/HER3 expression confirmed the HER2- status designated by IHC and/or ISH. Seventy-nine patient samples were analyzed for HER2 and HER3 expression using flow cytometry as described in the methods. The mean fluorescence intensity (MFI) of the samples were compared to three cell lines used as standards in the DAKO HercepTest. (SKBR3-DAKO 3+, MDA175vii- DAKO 1+, MDA231-DAKO 0). Size of the circles indicates the HER2 signaling CELsignia score. b Comparison of expression levels of HGF receptor (c-Met) to HGF response on 79 patient samples using flow cytometry as described in the methods. The size of the circles in both panels indicates the HER2 signaling CELsignia score

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Cell Communication and Signaling

ISSN: 1478-811X