Fig. 7From: CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngiomaSchematic diagram of the proposed mechanism supported by our results. Bmp2 increases miR-181b levels to directly target and inhibit CBX4 expression, leading to a reduction in CBX4-dependent regulation of HDAC4 nuclear translocation. Subsequently, this process promotes Runx2 activation (osteoblastic differentiation) and calcium deposition in ACPBack to article page