Fig. 2
From: Drug delivery strategy in hepatocellular carcinoma therapy
The mechanism of targeting strategies. A Schematic illustration of passive targeting. Enhanced vascular permeability, blood perfusion, and poor lymphatic drainage result in passive drug NP deposition and retention in tumor. B Schematic illustration of active targeting. Through utilizing specific ligands to bind specific complementary receptors on target cells, antitumor agents can be directed to the HCC site to exert a curative effect without damaging surrounding normal cells, tissues and organs, minimizing nonspecific uptake by untargeted cells to a great extent