Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Table 1 Summary of Reactome Gene Sets expression across comparisons in proteomics analysis

Pathway	WFS versus healthy			WFS after tunicamycin versus WFS before			Healthy after tunicamycin versus healthy before
Reactome unfolded protein response UPR	↓	− 1.97	0.001	↑	2.04	0.032	↑	1.46	0.083
Reactome protein folding	↑	2.09	0.004	↓	− 0.81	0.959	↑	1.41	0.106
Reactome degradation of Gli1 by the proteasome	↑	2.06	0.003	↑	1.22	0.372	↑	3.19	< 0.001
Reactome mitochondrial protein import	↓	− 2.18	< 0.001	↓	− 1.19	0.496	↓	− 2.18	< 0.001
Reactome respiratory electron transport	↓	− 2.59	< 0.001	↓	− 1.63	0.064	↓	− 2.64	< 0.001

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