Fig. 1From: Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and functionProtein expression in neuronic stem cells from WFS patients and controls before and after tunicamycin administration measured by proteomics experiment. A Log10 mean abundance of Wolframin across study groups. Whiskers represent standard deviation. One-way ANOVA p < 0.0001, p values of post-hoc Tukey tests are shown above corresponding groups; B Principle Component Analysis plot with annotated study groups. Arrows were added to components 1 and 2 as explanatory due to the observed effects of experimental reactions; C Heatmap with hierarchical clusterization performed on 50 proteins with the highest variance. Color scale represents row-standardized protein levels; D Volcano plot showing differential expression between WFS and healthy before tunicamycin administration. Significantly (FDR < 0.05) up-regulated (FC > 2) proteins are depicted in red and down-regulated (FDR < 0.05 and FC < 0.5) proteins are depicted in blueBack to article page