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Fig. 1. | Cell Communication and Signaling

Fig. 1.

From: Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Fig. 1.

17β-estradiol (E2)-induced DNA breaks and TFE3 breaks analysis. A Phosphorylation of H2AX (γH2AX) focis detected in HK-2 cells under 0.1% DMSO (solvent-only control) or 10 nM E2 treatment for 24 h or 48 h. B Quantification of the γH2AX focis in E2-treated cells as in panel A. C Pattern diagram of TFE3 break-apart rearrangement probe. D Examples of fusion and break-apart signal using TFE3 break-apart breaksfluorescence in situ hybridization (FISH) probe. E Quantification of the TFE3 break-apart signals in HK-2 cells under 0.1% DMSO (solvent-only control) or 10 nM E2 treatment for 48 h. Error bars indicate 95% confidence intervals (**p < 0.01; ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X