Fig. 4

MB49-derived exosomes promote the growth of tumor cells. A–C Total 1 × 10⁶ MB49 cells were subcutaneously injected to mice, DMSO or GW4869 (2.5 μg/g) were intraperitoneally injected every three days (n = 10, 5 mice in each group). A, B Mice were sacrificed at 15 d, and the ration of tumor/body weight were measured. C The tumor volume was measured every three days and the growth curve was shown. D, E The proportion of CD45⁺F4/80⁺CD206⁺ macrophage and CD4⁺/CD8⁺ T cells were measured by flow cytometry in tumors (n = 5). T-test; Mean ± SD, *P < 0.05; **P < 0.01; ***P < 0.001