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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

Fig. 1

The biosynthesis and metabolism of ceramide. Ceramide is both an end product and penultimate precursor for various sphingolipids, such as sphingomyelin, which is synthesized in the plasma membrane and glycosphingolipids. The enzymes involved in ceramide metabolism are shown in italics, compounds found or synthesized in the endoplasmic reticulum are in boldface type those found or synthesized in the Golgi apparatus are in normal type. The inhibitors used in our studies are outlined in red. (Adapted from [50]). Hypothesized locations of actions of excess NGF and of extra TRK receptors in the TrkA cells, addressed in Discussion, are also indicated

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Cell Communication and Signaling

ISSN: 1478-811X