Fig. 2
From: Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development
Actomyosin contractility and FGF signaling regulate adherens junction dynamics during Drosophila gastrulation. A During apical constriction of ventral mesoderm cells, increased contraction of the actin-myosin cytoskeleton mediates remodeling of adherens junction (AJ) complexes from sub-apical to apical positions. The polarity protein Par3 localizes to remodeled AJs, and Myosin II-generated tension protects AJs from Snail-mediated disassembly [32]. FGF receptor (Heartless) localizes with apical AJs, and FGF signaling modulates AJ number and cell division (not shown) during gastrulation and EMT [42]. B As Myosin II levels decrease, Snail activity leads to Par3 downregulation and AJ disassembly to promote EMT [32, 37]